C3 - Endothelial

Isoform switches

Marker split per cell-type:

Top 10 switching genes

EGFL7

CD36

ATP5F1C

GUK1

BTF3

MYL6

POLR1H

CCS

CAV1

GNAS

All isoform switching genes

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